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As opposed to the prescribed use of amphetamine medication,[8] tolerance is produced promptly in amphetamine abuse, therefore raising the level of the drug that is necessary to fulfill the habit.[9] Recurring amphetamine use can make "reverse tolerance", or sensitization to some psychological results.[10][eleven][12][13][fourteen] Several abusers will repeat the amphetamine cycle by using much more of the drug during the withdrawal. This causes an exceptionally unsafe cycle and may contain the usage of other drugs to recover from the withdrawal method. Abusers will commonly stay up for 2 or 3 times keeping away from the withdrawals then dose on their own with benzodiazepines or barbituates that will help them continue to be relaxed while they recuperate. The regular switching from uppers to downers could potentially cause critical damage to the CNS and brain.

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